Novel BRD4–NUT fusion isoforms increase the pathogenic complexity in NUT midline carcinoma
K Thompson-Wicking, RW Francis, A Stirnweiss… - Oncogene, 2013 - nature.com
… fusion and two novel isoforms. Knockdown by small interfering RNA in either cell line resulted
in decreased proliferation, increased … demonstrate that the novel BRD4–NUT fusion in PER…
in decreased proliferation, increased … demonstrate that the novel BRD4–NUT fusion in PER…
[HTML][HTML] A novel BRD4-NUT fusion in an undifferentiated sinonasal tumor highlights alternative splicing as a contributing oncogenic factor in NUT midline carcinoma
A Stirnweiss, K McCarthy, J Oommen, ML Crook… - Oncogenesis, 2015 - nature.com
… patient-derived tumor cells expressed a novel in-frame BRD4-NUT fusion transcript with …
Novel BRD4-NUT fusion isoforms increase the pathogenic complexity in NUT midline carcinoma…
Novel BRD4-NUT fusion isoforms increase the pathogenic complexity in NUT midline carcinoma…
NUT Carcinoma: Clinicopathologic features, pathogenesis, and treatment
CA French - Pathology international, 2018 - Wiley Online Library
… in-frame fusion gene encodes a BRD4-NUT fusion protein … identification of several novel
NUTM1-fusion partners, including … outcomes in NUT midline carcinoma of the head and neck. …
NUTM1-fusion partners, including … outcomes in NUT midline carcinoma of the head and neck. …
Pathogenesis of NUT midline carcinoma
CA French - Annual Review of Pathology: Mechanisms of …, 2012 - annualreviews.org
… involving NUT, usually BRD4-NUT fusion genes and, less commonly, … The short isoform is
nearly entirely included in BRD4-NUT, … BRD4-NUT fusion oncogene: a novel mechanism in …
nearly entirely included in BRD4-NUT, … BRD4-NUT fusion oncogene: a novel mechanism in …
[HTML][HTML] NUT midline carcinoma of the head and neck: current perspectives
M Napolitano, M Venturelli, E Molinaro… - OncoTargets and …, 2019 - ncbi.nlm.nih.gov
… 1 ,2 , 3 – 5 ,5, 6 – 18 Although three isoforms of the BRD4 … of the oncogenic chromatin
complex in BRD4–NUT cells. ZNF532, as … Birabresib (MK-8628/OTX015) is a novel BET inhibitor …
complex in BRD4–NUT cells. ZNF532, as … Birabresib (MK-8628/OTX015) is a novel BET inhibitor …
NSD3–NUT fusion oncoprotein in NUT midline carcinoma: implications for a novel oncogenic mechanism
… in BRD4–NUT-expressing NMCs. These findings identify NSD3 as a … complex with similar
function to BRD4–NUT. Indeed, siRNA knockdown of BRD4, both long and short isoforms, …
function to BRD4–NUT. Indeed, siRNA knockdown of BRD4, both long and short isoforms, …
Activation of SOX2 Expression by BRD4-NUT Oncogenic Fusion Drives Neoplastic Transformation in NUT Midline Carcinoma
… -cut to bypass the complex process of accumulating genetic … as naturally occurring long
and short isoforms. The t(15;19) … Our study identifies SOX2 as a novel target for BRD4-NUT as …
and short isoforms. The t(15;19) … Our study identifies SOX2 as a novel target for BRD4-NUT as …
BRD4-NUT Fusion Oncogene: A Novel Mechanism in Aggressive Carcinoma
CA French, I Miyoshi, I Kubonishi, HE Grier… - Cancer research, 2003 - AACR
… pathogenetic role in this extremely lethal form of carcinoma. … likely to be complex in the
t(15;19) carcinoma. One scenario … of BRD4 long isoform; (b) increased avidity of BRD4-NUT in …
t(15;19) carcinoma. One scenario … of BRD4 long isoform; (b) increased avidity of BRD4-NUT in …
Supercharging BRD4 with NUT in carcinoma
KP Eagen, CA French - Oncogene, 2021 - nature.com
… Recently, MDs were found to form a novel nuclear sub-… NUT carcinoma (NC, aka NUT midline
carcinoma) is a rare … interactors of BRD4-NUT compared with those of the short isoform of …
carcinoma) is a rare … interactors of BRD4-NUT compared with those of the short isoform of …
[HTML][HTML] NUT carcinoma: clinicopathologic features, molecular genetics and epigenetics
V Moreno, K Saluja, S Pina-Oviedo - Frontiers in Oncology, 2022 - frontiersin.org
… result in the development of possible novel targeted therapies. … involving the NUT midline
carcinoma family member 1 (… its fusion with NUTM1 results in a powerful oncogenic complex. …
carcinoma family member 1 (… its fusion with NUTM1 results in a powerful oncogenic complex. …